The impact of ambroxol on the anti-inflammatory effect of azithromycin in lung tissue

The aim of this study was to compare the effects two different doses ambroxol (AMB) co-administered with azithromycin (AZIT) on concentrations bronchoalveolar lavage fluid (BALF) cytokines and serum biochemical parameters in an lipopolysaccharide (LPS)-induced acute lung injury mouse model. A total 78 male Swiss albino mice were used for investigation. After six had been separated as control group (0 hours), remaining animals divided into following three equal groups: LPS, LPS+AZIT+AMB30 LPS+AZIT+AMB70. AZIT AMB administered intraperitoneally. BALF samples collected before hour) after applications at 4, 8, 16 24 hours under general anaesthesia, then all euthanised by cervical dislocation. Concentrations tumor necrosis factor (TNF)α, interleukin (IL)-6 IL-10 aspartate aminotransferase (AST), alkaline phosphatase (ALP), urea creatinine determined. Elevated TNFα IL-6 LPS prevented 8 group. In addition, both treatment groups inhibited elevated hours. LPS+AZIT+AMB70 increased 4 hours, respectively. caused significant elevations sampling times statistical fluctuations other times. ALP concentration decreased conclusion, combination low-dose may achieve beneficial pulmonary infections influencing cytokine network.